25 Clinical Research Studies

General information about Mānuka, what is it, why it cost so much

This paper reports on three hospice patients for whom topical manuka honey (MH), applied daily, improved ulcers contaminated with methicillin-resistant Staphylo- coccus aureus (MRSA). A 59-year-old male with prostate cancer and multiple sclerosis bought a new wheelchair without a proper fitting session.

Positive effect of Mānuka Honey on Health and body immune system

Honey properties are determined by the level of methylglyoxal (antimicrobial substance) from 30 to 550 in the case of MGO method or from 5 to 20 by UMF method. Previous studies have shown that high levels of methylglyoxal in Manuka honey support the body’s defense mechanisms,mainly by stimulating the growth of probiotic intestinal bacteria.

Mānuka Honey as an alternative to, or as an adjunct with, other wound care treatment modalities for wound infections

Historically, honey has been used as a homeopathic remedy for a wide variety of ailments. However, little has been known about its natural healing properties. Today, several therapeutic characteristics have been identified in specific types of honey derived from plants native to Australia and New Zealand.

Case studies of 3 patients, Mānuka Honey improved ulcers contaminated with methicillin resistant Staphylococcus aureus

This paper reports on three hospice patients for whom topical manuka honey (MH), applied daily, improved ulcers contaminated with methicillin-resistant Staphylo- coccus aureus (MRSA).
A 59-year-old male with prostate cancer and multiple sclerosis bought a new wheelchair without a proper fitting session.

The inhibitory effect of Mānuka Honey on human colon cancer

Globally, colorectal cancer (CRC) is the third most widespread cancer in both men and women; over 1 million new cases are diagnosed each year accounting for 9.7% of all cancers, and consequently, more than 693 933 deaths per annum corres- ponding to 8.5% of the total number of cancer deaths.

The Effectiveness of Mānuka Honey as an Alternative Therapy in the Management of Wounds

The current review, which involved searching through information held at UWIC’s library, the Highwire journal database, the Web of Knowledge database, and a number of journal abstracts, examines recent theories both for and against the application of manuka honey in the treatment of wounds, and the efficacy of such treatment.

Successful use of honey to manage a diversity of wound aetiologies

Despite advances in molecular biology, the development of various tissue-engineered skin substitutes and growth factors, and a range of other therapeutic options, chronic ulceration remains a significant problem in our society (1). Wounds research continues to increase at macroscopic, microscopic and molecular level and aims to enhance our understanding of wound healing and ulti- mately improve patient care outcomes.

Researches’ review of antimicrobial effects of Mānuka Honey

Medicinal honey research is undergoing a substantial renaissance. From a folklore remedy largely dismissed by mainstream medicine as “alternative”, we now see increased interest by scientists, clinical practitioners and the general public in the therapeutic uses of honey. There are a number of drivers of this interest: first, the rise in antibiotic resistance by many bacterial pathogens has prompted interest in developing and using novel antibacterials;

Case study of wound care: Effect of Mānuka Honey on six different types of wounds

When referring to honey in this study, I am referring to medical Manuka honey from New Zealand. It has special properties not found in normal honey. Normal “food” honey is not recommended for wound care. Honey as a wound care treatment has been known for many years. In the 1960’s and 1970’s it became less popular because of the era of modern antibiotic medicine, but infectious diseases are currently the third leading cause of death in the USA and the second leading cause of death worldwide.

Mānuka Honey as a tissue engineering essential ingredient

A renewed interest in medical-grade honey is revitalizing the clinical and biomedical engineering communities. The primary driving force for this revitalization has been the goal of developing non-antibiotic alternatives and effective new ways to prevent and fight bacterial infections. This application of honey is not unexpected or new since the use of medicinal honey simply fell out of fashion when antibiotics revolutionized medicine over one hundred years ago.

An in vitro study on a potential agent of Mānuka Honey and domestic beekeeper honey against Porphyromonas gingivalis

Honey has been discussed as a therapeutic option in wound healing since ancient time. It might be also an alternative to the commonly used antimicrobials in periodontitis treatment. The in-vitro study was aimed to determine the antimicrobial efficacy against Porphyromonas gingivalis as a major periodontopathogen.

Mānuka Honey is an effective alternative antibacterial product to silver for the prevention and management of wound infection

Honey and silver are traditional wound therapies that are still used in modern clinical practice. Whereas silver is one of the most common antimicrobial agents used in wound management (Leaper, 2011), more scepticism surrounds the use of honey, despite accumulating evidence of its efficacy in vitro and in vivo.

Honey as a promising treatment for diabetic foot ulcers (DFU)

Diabetic Foot Ulcers (DFUs) are complex, chronic wounds, which have a major long-term impact on the morbidity, mortality and quality of patients’ lives. Individuals who develop a DFU are at greater risk of premature death, myocardial infarction, and fatal stroke than those without a history of DFU.

Mānuka Honey dressings treated penile denudation successfully, while STSG (Split-Thickness Skin Graft) failed

Penile denudation is a rare and devastating injury with potential loss of sexual function and imperilled aesthetic appearance. Not many cases have been reported, although the aetiologies revolve around animal bites, trauma from the use of power-driven tools, burns, infections, and circumcisions.

Mānuka Honey offers an effective way of treating infections caused by organism

Manuka honey originates from the manuka tree (Leptospermum scoparium) and its antimicrobial effect has been attributed to a property referred to as Unique Manuka Factor that is absent in other types of honey. Antibacterial activity of Manuka honey has been documented for several bacterial pathogens, however there is no information on Clostridium difficile, an important nosocomial pathogen.

Mānuka Honey might be a useful candidate for the inhibition of nasal polyp formation

Manuka honey has anti-microbial, anti-inflammatory, and anti-proliferative action with a high concentration of methylglyoxal compound. It is also effec- tive in killing Staphylococcus aureus biofilm and effective for the acute exacerbation of chronic rhinosinusitis. The aim of this study was to determine the anti-fibrotic effect of manuka honey in nasal polyp fibroblasts.

Mānuka Honey properties can be utilised within modern veterinary practice

Wound management can be a challenging and confusing subject. With numerous products at our disposal and ever-changing advances in wound management techniques, it can become overwhelming trying to make the best clinical decision to suit patients. With the increasing awareness and concern of antibiotic resistance, and a holistic approach to veterinary medicine being sought by clients, the new and old ways of treating wounds are under scrutiny.

Mānuka honey provides the advantages to the modern pharmacopeia with combination of antibacterial and anti-inflammatory activities providing promise for problematic chronic conditions while delivering those activities in a context sufficiently gentle that it can be used in direct applications to the eye and for use in children

Honey has been used since 2500 BC as a wound dressing, its physical properties allowing it to serve as a viscous ointment for .

Non-peroxide antimicrobial activity of Mānuka Honey (dose-dependent)

Honey is an ancient natural remedy for the treatment of infected wounds. It has regained attention in the medical profession, as it has recently been reported to have a broad-spectrum inhibitory effect against bacteria. Data concerning Manuka honey of New Zealand origin, which is claimed to provide additional non-peroxide antimicrobial activity (so-called standard NPA) against oral pathogens, is still scarce.

Antibacterial activity of varying UMF-graded Mānuka honeys (lower MIC were observed with UMF 5+ compared to UMF 10+ and UMF15+)

Honey has been used as a traditional remedy for skin and soft tissue infections due to its ability to promote wound healing. Manuka honey is recognized for its unusually abundant content of the antibacterial compound, methylglyoxal (MGO).

Antibacterial Potential of Honey Different Origins

The antibacterial activity of honey is well documented, this activity is mainly due to its low pH, osmolarity and hydrogen peroxide accumulation. Recently, more attention has been given to the importance of a unique extra antimicrobial activity, termed as a non- peroxide activity.

Mānuka Honey is an effective antibacterial agent that can be enhanced by complexing with alfa-cyclodextrin

Manuka honey is recognized for it’s health-promoting properties and it’s use in medicine is well documented. However, the actions of Manuka honey are limited by rapid digestion and the inactivation of bioactive components such as methylglyoxal.

Mānuka Honey of different UMF values has medicinal properties of interest and it can be beneficial when used as a combination treatment with other antimicrobial agents

The importance of honey for medicinal purposes is well documented in some of the world’s oldest literature. Honey is well known and studied for its antimicrobial properties. The medicinal properties in honey originate from the floral source used by bees.

The glycaemic index of Mānuka Honey

aims: Rates of obesity and diabetes are increasing in Western populations, and it is sug- gested that these diseases can be moderated, in part, by consuming foods that produce a low blood sugar response. Anecdotally honeys are thought to be comparable to simple sugars for sweetness and gly- caemic response, although little is currently known about the medically beneficial Manuka honey from New Zealand.

Mānuka Honey might be able to reduce oral pathogens within dental plaque (to be able to control dental biofilm deposit)

Honey has been used since ancient times and more recently, for the healing of wounds and against infectious diseases. The aim of our study was to investigate the effect of two manuka honeys showing different potencies of their antibacterial activity, on potentially pathogenic oral bacteria. The antimicrobial activity was examined by determining the MIC and MBC using the macro dilution broth technique. The effect on the adherence was tested on growing cells of Streptococcus mutans on a glass surface and on a multi-species biofilm grown on saliva-coated hydroxyapatite discs.